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KMID : 1134819970260010148
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 1 p.148 ~ p.153
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Studies on the Immunomodulating Effects of Polysaccharide Extracted from Ganoderma lucidum on Macrophage
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Kim Sung-Hwan
Kim Eul-Sang
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Abstract
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The immunomodulating effects of polysaccharide extracted from Ganoderma lucidum(PSG) on macrophage were evaluated using murine macrophage cell line ATCC TIB 71 cells or peritoneal exudate cells of BALB/c mice. The cell were incubated with various content of PSG for 24 hours at 0.5% CO₂ incubator under varying experimental conditions. PSG stimulated the non-specific activites of macrophage such as mitotic activity and expression of surface interleukin-2 receptors by dose-dependent pattern with statistic significance(p＜0.001); however, PSG had little immunoregulatory effects on cytokines derived from peritoneal macrophages of BALB/c mice. There were no significant changes in the secretion of interleukin-1, interleukin-6, or tumor necrosis factors(TNF) of PSG treated cells compared to the control group. But PSG increased secretion of cytokines(IL-1 and TNF) when the cells were primed and trigged with BCG and IFN-γ.
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KEYWORD
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Ganoderma lucidum, macrophage, immunomodulating effects, mitotic activity, interleukin-2, cytokines
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